PoplarV1, Main, Exploration, bibRecord, 002012

The essential oil of Populus balsamifera buds: its chemical composition and cytotoxic activity.

Identifieur interne : 002012 ( Main/Exploration ); précédent : 002011; suivant : 002013

The essential oil of Populus balsamifera buds: its chemical composition and cytotoxic activity.

Auteurs : Marianne Piochon-Gauthier ; Jean Legault ; Muriel Sylvestre ; André Pichette

Source :

Natural product communications [ 1934-578X ] ; 2014.

RBID : pubmed:24689304

Descripteurs français

KwdFr :
- Antinéoplasiques d'origine végétale (pharmacologie), Apoptose (effets des médicaments et des substances chimiques), Chromatographie en phase liquide à haute performance (MeSH), Huile essentielle (analyse), Huile essentielle (pharmacologie), Humains (MeSH), Lignée cellulaire tumorale (MeSH), Populus (composition chimique).
MESH :
- analyse : Huile essentielle.
- composition chimique : Populus.
- effets des médicaments et des substances chimiques : Apoptose.
- pharmacologie : Antinéoplasiques d'origine végétale, Huile essentielle.
- Chromatographie en phase liquide à haute performance, Humains, Lignée cellulaire tumorale.

English descriptors

KwdEn :
- Antineoplastic Agents, Phytogenic (pharmacology), Apoptosis (drug effects), Cell Line, Tumor (MeSH), Chromatography, High Pressure Liquid (MeSH), Humans (MeSH), Oils, Volatile (analysis), Oils, Volatile (pharmacology), Populus (chemistry).
MESH :
- chemical , analysis : Oils, Volatile.
- chemical , pharmacology : Antineoplastic Agents, Phytogenic, Oils, Volatile.
- chemistry : Populus.
- drug effects : Apoptosis.
- Cell Line, Tumor, Chromatography, High Pressure Liquid, Humans.

Abstract

The chemical composition of Populus balsamifera essential oils obtained from spring buds, fall buds, and young leaves were determined by GC and GC-MS analyses. The major constituent, (+)-alpha-bisabolol, a rare sesquiterpene, was isolated from spring oil using reverse-phase preparative HPLC. The cytotoxic activity of balsam poplar oils and isolated (+)-alpha-bisabolol was assessed in vitro against human lung carcinoma (A549) and colorectal adenocarcinoma (DLD-1) cell lines. Essential oils were cytotoxic with IC50 ranging from 35 to 50 microg/mL. (+)-alpha-Bisabolol exhibited pronounced activity (IC50 14 microg/mL) against both cancer cell lines. It also exhibited interesting cytotoxic activity (IC50 23 microg/mL) against human glioma (U251), higher than the one observed for (-)-alpha-bisabolol (IC50 34 microg/mL), which is known for its apoptosis-inducing effect against glioma cells.

PubMed: 24689304

Affiliations:

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Le document en format XML

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<author><name sortKey="Legault, Jean" sort="Legault, Jean" uniqKey="Legault J" first="Jean" last="Legault">Jean Legault</name>
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<term>Chromatographie en phase liquide à haute performance (MeSH)</term>
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<term>Huile essentielle (pharmacologie)</term>
<term>Humains (MeSH)</term>
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<front><div type="abstract" xml:lang="en">The chemical composition of Populus balsamifera essential oils obtained from spring buds, fall buds, and young leaves were determined by GC and GC-MS analyses. The major constituent, (+)-alpha-bisabolol, a rare sesquiterpene, was isolated from spring oil using reverse-phase preparative HPLC. The cytotoxic activity of balsam poplar oils and isolated (+)-alpha-bisabolol was assessed in vitro against human lung carcinoma (A549) and colorectal adenocarcinoma (DLD-1) cell lines. Essential oils were cytotoxic with IC50 ranging from 35 to 50 microg/mL. (+)-alpha-Bisabolol exhibited pronounced activity (IC50 14 microg/mL) against both cancer cell lines. It also exhibited interesting cytotoxic activity (IC50 23 microg/mL) against human glioma (U251), higher than the one observed for (-)-alpha-bisabolol (IC50 34 microg/mL), which is known for its apoptosis-inducing effect against glioma cells.</div>
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<Abstract><AbstractText>The chemical composition of Populus balsamifera essential oils obtained from spring buds, fall buds, and young leaves were determined by GC and GC-MS analyses. The major constituent, (+)-alpha-bisabolol, a rare sesquiterpene, was isolated from spring oil using reverse-phase preparative HPLC. The cytotoxic activity of balsam poplar oils and isolated (+)-alpha-bisabolol was assessed in vitro against human lung carcinoma (A549) and colorectal adenocarcinoma (DLD-1) cell lines. Essential oils were cytotoxic with IC50 ranging from 35 to 50 microg/mL. (+)-alpha-Bisabolol exhibited pronounced activity (IC50 14 microg/mL) against both cancer cell lines. It also exhibited interesting cytotoxic activity (IC50 23 microg/mL) against human glioma (U251), higher than the one observed for (-)-alpha-bisabolol (IC50 34 microg/mL), which is known for its apoptosis-inducing effect against glioma cells.</AbstractText>
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The essential oil of Populus balsamifera buds: its chemical composition and cytotoxic activity.

The essential oil of Populus balsamifera buds: its chemical composition and cytotoxic activity.

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki